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Abstract Nowadays, global warming, economic problems affect the business operation. Especially, Small and Medium Enterprise (SMEs). The objective of this study is 1) to study the level of importance of sustainable development goals (SDGs) and the factors that motivate business operations of SMEs 2) to study the factors of business characteristics of SMEs affecting the SDGs and 3) to analyze factors of business characteristics of SMEs that influence the business operation according to the overall SDGs. This study deploys quantitative method and using percentage, mean, S.D., anova and multiple regression for analysis data and using a survey questionnaire collected from 148 samples.The study found out that SMEs focus on Sustainable Development Goals (SDGs) in Responsible consumption and production at the highest level (x̅ = 4.28) and found that SMEs focus on motivate business operations factors in Compliance with laws / regulations at the highest level (x̅ = 4.27). Production, Wholesale and Retail business focus on SDGs in Ensure inclusive and equitable quality education and promote lifelong learning opportunities for all (SDG4), End poverty in all its forms everywhere (SDG1) and Ensure healthy lives and promote well-being for all at all ages (SDG3). Moreover, the study also found out that business expansion into environmentally friendly markets factors influencing business operations in accordance with the guidelines for SDGs of SMEs.
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